Was ist Aufklärung?

Berlinische Monatsschrift, Dezemberausgabe 1784 in Beantwortung der Frage: Was ist Aufklärung? –

Immanuel Kant: „Aufklärung ist der Ausgang des Menschen aus seiner selbst verschuldeten Unmündigkeit. Unmündigkeit ist das Unvermögen, sich seines Verstandes ohne Leitung eines anderen zu bedienen. Selbstverschuldet ist diese Unmündigkeit, wenn die Ursache derselben nicht am Mangel des Verstandes, sondern der Entschließung und des Mutes liegt, sich seiner ohne Leitung eines andern zu bedienen. Sapere aude! Habe Mut, dich deines eigenen Verstandes zu bedienen! ist also der Wahlspruch der Aufklärung.“


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Orthomolekulare Ärztliche Kunstfehler


Clinical Guide to the Use of Vitamin C The Clinical Experiences of Frederick R. Klenner, M.D., abbreviated, sumarized and annotated by Lendon H. Smith, M.D. 2233 SW Market Street, Portland, Oregon 97201

Clinical Guide to the Use of Vitamin C

The Clinical Experiences of Frederick R. Klenner, M.D.,
abbreviated, sumarized and annotated by
Lendon H. Smith, M.D. – 2233 SW Market Street, Portland, Oregon 97201



The History of Orthomolecular Medicine

Orthomolecular Hall Of Fame information has been provided by
Dr. Andrew W. Saul www.doctoryourself.com and by the Journal Of Orthomolecular Medicine.


The importance of diet in relationship to optimal health has been understood throughout recorded history. Hippocrates regarded food as a primary form of medicine more than 2,500 years ago. Records from ancient Egypt as far back as 5000 BC show the use of specific foods to treat various conditions.

True scientific understanding of diet did not occur until the 18th century, beginning with the work of French physicist Rene de Reaumur, who is credited with conducting the initial research of digestive chemistry. Later in that same century, Reaumur’s work was built upon by chemist Antoine Laurent Lavoisier, who, prior to being guillotined during the French Revolution, provided the scientific foundation for the study of how the body metabolizes food to create energy.


The first person to show a direct link between disease and a lack of a specific nutrient was James Lind, a physician in the British navy, who discovered that sailors on long voyages without rations containing citrus fruits developed bleeding gums, rough skin, poor muscle tension, and slow-healing wounds, all symptoms characteristic of scurvy. In 1757, in one of the first controlled medical experiments, Lind demonstrated that when sailors were supplied with lemons, limes, and oranges, scurvy could be prevented. As a result of his findings, Captain James Cook made it mandatory that every English sailor be supplied with rations of lemons and limes, enabling to sail around the world scurvy-free, as well as supplying them with the nickname „limeys.“ Today, it is well known that scurvy is due to vitamin C deficiency.


Christiaan Eijkman

Christiaan Eijkman, a Dutch physician, is famous for his nutritional research. In 1893 he discovered that a diet of polished (overkvernet) rice causes beriberi, and was able to produce the disease experimentally in birds. He discovered vitamin B.

In 1897, Christiaan Eijkman proved that an element in unpolished rice was essential to proper functioning of the nervous system and carbohydrate metabolism, and that a deficiency in that ingredient could cause beriberi and other diseases. In 1929, his research resulted in him sharing the Nobel Prize with British biochemist Sir Frederick Gowland Hopkins for physiology and medicine.


Max Gerson, MD
Hall of Fame 2005

„I know of one patient who turned to Gerson Therapy having been told she was suffering from terminal cancer and would not survive another course of chemotherapy. Happily, seven years later, she is alive and well. So it is vital that, rather than dismissing such experiences, we should further investigate the beneficial nature of these treatments.“
— H.R.H. Charles, Prince of Wales

In the late 1920s, Max Gerson, M.D., began observing that cancer could be cured with nutrition in tandem with systemic detoxification. Charlotte Gerson writes: „Dr. Gerson found that the underlying problems of all cancer patients are toxicity and deficiency. One of the important features of his therapy was the hourly administration of fresh vegetable juices. These supply ample nutrients, as well as fluids to help flush out the kidneys. When the high levels of nutrients re-enter tissues, toxins accumulated over many years are forced into the blood stream. The toxins are then filtered out by the liver. The liver is easily overburdened by the continuous release of toxins and is unable to release the load… Dr. Gerson found that he could provide help to the liver by the caffeine in coffee, absorbed from the colon via the hemorrhoidal vein, which carries the caffeine to the portal system and then to the liver. The caffeine stimulates the liver/bile ducts to open, releasing the poisons into the intestinal tract for excretion.“

The Gerson Therapy is not specifically a cancer treatment but rather a metabolic treatment, one that cleanses while strengthening the body’s ability to heal itself. Not surprisingly, the program is effective against a wide variety of serious illnesses. Dr. Gerson’s approach has been shown, for over seven decades, to greatly improve both quality and length of life in the sickest of patients.

There is no higher compliment possible than this summation by the great Albert Schweitzer, M.D., Nobel Prize laureate: „I see in Dr. Max Gerson one of the most eminent geniuses in medical history.“


William McCormick, M.D.
Hall of Fame 2004

„Vitamin C is a specific antagonist of chemical and bacterial toxins.“

Over 50 years ago, it was Toronto physician William J. McCormick, M.D., who pioneered the idea that poor collagen formation, due to vitamin C deficiency, was a principal cause of diverse conditions ranging from stretch marks to cardiovascular disease and cancer. This theory would become the foundation for Linus Pauling and Ewan Cameron’s decision to employ large doses of vitamin C to fight cancer.

Over twenty years before Pauling, McCormick had already reviewed the nutritional causes of heart disease and noted that four out of five coronary cases in hospital show vitamin C deficiency. McCormick also early proposed vitamin C deficiency as the essential cause of, and effective cure for, numerous communicable illnesses, becoming an early advocate of using vitamin C as an antiviral and an antibiotic. Modern writers often pass by the fact that McCormick actually advocated vitamin C to prevent and cure the formation of some kidney stones as far back as 1946. And fifty years ago, McCormick „found, in clinical and laboratory research, that the smoking of one cigarette neutralizes in the body approximately 25 mg of ascorbic acid.“ His early use of gram-sized doses to combat what then and now are usually regarded as non-deficiency-related illnesses set the stage for today’s 100,000 mg/day antiviral/ anticancer vitamin C IV’s.


Albert von Szent-Györgyi, PhD
Hall of Fame 2005

„Discovery consists of seeing what everybody has seen, and thinking what nobody has thought.“
— Albert Szent-Györgyi

Dr. Szent-Györgyi depended on thought, as did Pauling, rather than on equipment.“ wrote Abram Hoffer. Albert Szent Györgyi was born in Hungary and spent the First World War in the Austrian army. After the war, he studied at Groningen and with Hopkins at Cambridge. C. It was here that he became interested in a chemical agent, present in plant juices, which had the effect of delaying oxidation, such as the browning of a sliced apple exposed to the air. He suggested that this agent, which was also present in cabbages and oranges, was the mysterious Vitamin. By 1933, he had isolated the substance in kilogram lots and named it „ascorbic acid“ which means „the acid which prevents scurvy.“ „During World War II, Szent Györgyi was in constant danger from the Nazis and finally took refuge in the Swedish legation in Budapest. The Gestapo raided the legation but he escaped and remained in hiding for the rest of the war. He was rescued by the Russian armies and taken to Moscow on the direct orders of Molotov. He was well treated by the Russians but, knowing he could not work in their system, he went to the United States in 1947 where he settled at the Marine Biological Laboratories at Woods Hole, Massachusetts.“ (Excerpted from Albert Szent-Györgyi and Vitamin C, by Nigel Bunce and Jim Hunt, University of Guelph, 1987) „Albert Szent-Györgyi, PhD, won the 1937 Nobel Prize for his discovery of vitamin C. In fact, it was he who named the vitamin ascorbic acid and first predicted its use in cancer. When Szent-Györgyi was on his deathbed, at the age of 93, Linus Pauling flew from California to Szent-Györgyi’s home at Woods Hole, Mass., to say goodbye. Holding his hand, Linus said wistfully, „You know, Albert, I always thought that someday we two would work together.“ Szent-Györgyi looked up and said, humorously, „Well, if not in this life, then maybe in the next.“ Pauling himself died a few years later, also at age 93. They were two of the greatest thinkers of the 20th century. „(Ralph W. Moss, Ph.D., Cancer Decisions Newsletter, July 18, 2004)


Roger J. Williams, Ph.D.
Hall of Fame 2004

„When in doubt, try nutrition first.“

Another pioneer in the concept of orthomolecular nutrition was Roger Williams, Professor of Chemistry, discoverer of pantothenic acid (vitamin B5 ), and founder and director of the Clayton Foundation Biochemical Institute at the University of Texas which, under the directorship of Dr. Williams, was responsible for more vitamin related discoveries than any other laboratory in the world. He also developed the concept of Genetotrophic disease.

According to Williams, the following thesis formed the basis of this new approach to nutrition: „the nutritional microenvironment of our body cells is crucially important to our health, and deficiencies in this enviromnent consititute a major cause of disease.“


Cornelius Moerman, MD
Hall of Fame 2005

The best word to describe the Dutch physician, Cornelius Moerman, would be „steadfast.“ He withstood the strongest opposition of his colleagues during his entire professional life. Even today in the Netherlands, his name remains symbolic, forever connected to nutritional therapy, especially of cancer. Prior to World War II, Dr. Moerman published his view that cancer is not a local disease, but the tumor is the end stage of the deterioration of the total body. Strengthening the immune system, he said, is the answer to this disease, and nutrition plays the central role.

Moerman, a passionate pigeon-fancier, observed that healthy birds did not develop cancer, whereas the weak and malnourished ones did. He argued, based on his own experiments with his pigeons, that cancer was a derangement of metabolism, a deficiency of iodine, citric acid, B-vitamins, iron, sulphur, and the vitamins A, D, E and later C. A strictly proper diet, supplemented with these substances, forms the basis of the Moerman therapy.

Cutting-edge nutritional science has now caught up with Dr. Moerman’s viewpoint. His principles for the treatment of cancer were, at the time, revolutionary. In September, 1976, Moerman was invited by Linus Pauling to the conference of the International Association of Cancer Victors and Friends in Los Angeles. As the guest of honour, Moerman received an award for his valuable work with cancer patients and for his original approach to the treatment of cancer. Meeting Moerman, Dr. Linus Pauling praised him and considered him to be one of his peers in the fight for the acceptance of nutritional medicine.

Cornelius Moerman’s work lives on today in the „Moermanvereniging,“ an ever-growing Dutch association of patients who advocate nutritional therapy for cancer.

Submitted by Dr. Gert Schuitemaker, President, ISOM


Wilfrid Shute, M.D. Evan Shute, M.D.
1907-1982 1905-1978
Hall of Fame 2004

In 1933 Drs. Wilfred and Evan Shute were some of the first doctors to use large doses of vitamin E to treat heart disease. At that time, antioxidants and free radicals were rather obscure concepts in the chemistry of oxidation, far removed from issues of health and disease. Also at that time, using vitamins to treat serious diseases such as heart disease and diabetes was considered by the medical establishment as misguided at best and outright fraud at worst. Yet thanks to the observant practitioners such as the Shutes who were more interested in what helped their patients most, medical researchers became motivated to study it scientifically. The results would speak for themselves.

For decades, vitamin E was lampooned as a „cure in search of a disease.“ In 1985, Linus Pauling wrote: „The failure of the medical establishment during the last forty years to recognize the value of vitamin E in controlling heart disease is responsible for a tremendous amount of unnecessary suffering and for many early deaths. The interesting story of the efforts to suppress the Shute discoveries about vitamin E illustrates the shocking bias of organized medicine against nutritional measures for achieving improved health.“ Dr. Pauling would most likely have appreciated this comment from a recent Harvard Health Letter: „A consistent body of research indicates that vitamin E may protect people against heart disease…The data generally indicate that taking doses ranging from 100 to 800IU per day may lower the risk of heart disease by 30%-40%.“ Over half a century ago, the Shute brothers and colleagues showed that, with even higher doses than those, and with an insistence on the use of natural vitamin E, the results are better still.

Today’s growing appreciation of the role of d-alpha tocopherol in preventing and reversing cardiovascular disease is due primarily to the Shute brothers.

„We didn’t make vitamin E so versatile. God did. Ignore its mercy at your peril.“
— Dr. Evan Shute


Frederick Klenner, MD
Hall of Fame 2005

„Vitamin C is the safest substance available to the physician.“
— Frederick Klenner, M.D.

Born in Pennsylvania, Dr. Klenner received his medical degree from Duke University in 1936. After three years post-graduate training to specialize in diseases of the chest, Dr. Klenner continued his general practice. „His patients were as enthusiastic as he in playing guinea pigs to study the action of ascorbic acid. The first massive doses of ascorbic acid he gave to himself. Each time something new appeared on the horizon he took the same amount of ascorbic acid to study its effects so as to come up with the answers‘ (Journal of Applied Nutrition, 23: 3 & 4, 1971).

Abram Hoffer writes: „In the early 1950s, Dr. Fredrick Klenner began his work with megadoses of vitamin C. He used doses up to 100 grams per day orally or intravenously. In clinical reports he recorded the excellent response he saw when it was given in large doses. For example, polio patients given vitamin C suffered no residual defects from their polio. A controlled study in England on 70 children, half given vitamin C and half given placebo, confirmed that none of the ascorbatetreated cases developed any paralysis while up to 20 percent of the untreated group did. This study was not published because the Salk Vaccine had just been developed and no one was interested in vitamins. Dr. Klenner’s work was ignored.“

Dr. Klenner was the first physician to emphasize that small amounts of ascorbate do not work. He said, „If you want results, use adequate ascorbic acid.“ As a result of seeing consistent cures of a great variety of viral and bacterial diseases with huge doses of vitamin C, he published over twenty medical reports. Orthodox medicine’s rejection of his lifesaving work stands as a reminder to all medical mavericks practising today. „Some physicians,“ Klenner wrote, „would stand by and see their patient die rather than use ascorbic acid because, in their finite minds, it exists only as a vitamin.“


Irwin Stone, Ph.D.
Hall of Fame 2004

Humanity can thank biochemist Irwin Stone for introducing Linus Pauling to vitamin C. Pauling spoke of this highly influential first contact, when Stone sent him „copies of some papers that he had just published, with the general title ‚Hypoascorbemia, a Genetic Disease‘. . . The 3,000 milligrams per day that he recommended is 50 times the RDA. My wife and I began taking this amount of the vitamin … (and) the severe colds that I had suffered from several times a year all of my life no longer occurred. After a few years I increased my intake of vitamin C to 100 times; then 200 times, and then 300 times the RDA (now 18,000 mg per day).

„Among the several arguments Irwin Stone presented to support his thesis that the proper physiological intake of vitamin C is 50 or more times the RDA were two that especially impressed me. . . Almost all animal species — dogs, cats, cows, horses, elephants, and so on — have continued to synthesize ascorbate. . . The second fact that impressed me is that animals manufacture very large amounts of ascorbate. The amount manufactured is approximately proportional to the body weight, and, converted to the weight of a human being, ranges from about 2,000 to 20,000 milligrams per day. Irwin Stone concluded that human beings with an average diet are accordingly all suffering from hypoascorbemia, a deficiency of ascorbate in the blood and tissues.“ (Linus Pauling in His Own Words : Selections from his Writings, Speeches and Interviews, edited by Barbara Marinacci. NY: Simon and Shuster, 1995). There could be no finer tribute to Irwin Stone than this.

In Memoriam: Irwin Stone, Ph.D.


Carl C. Pfeiffer, M.D., Ph.D.
Hall of Fame 2004

„For every drug that benefits a patient, there is a natural substance that can achieve the same effect.“ — Pfeiffer’s Law

Carl C. Pfeiffer made his first contribution in 1974, contributing 22 papers by the time he died in 1988. He made major contributions to the understanding of trace element and mineral metabolism in the schizophrenias; made a rational division of the schizophrenias into three biochemical groups, and discussed amino acids in medicine. His contributions were of the greatest value. Carl Pfeiffer was one of the original members of the Committee on Therapy of the American Schizophrenia Association.

„If there’s a drug that can alter the brain’s biochemistry, there’s usually a combination of nutrients that can achieve the same thing without side-effects,“ said Dr. Pfeiffer, founding director of the Brain Bio Center in Princeton, New Jersey (1973). Dr. Pfeiffer spent most of his life researching for the causes and cure of mental illness. He found that biochemical imbalances in the body were the blame for many psychological problems. His study on more than 20,000 schizophrenic patients enabled him to divide schizophrenia into 3 biochemical groupings called histapenia, histadelia and pyroluric 2, 3.

Lendon Smith, MD, a supporter of the Pfeiffer approach, wrote: „Carl C. Pfeiffer, in his book, Nutrition and Mental Illness, listed well-known causes of schizophrenia. . . He said, ‚All of these are chemically-induced metabolic disorders, which suggests the strong possibility that the „true“ schizophrenias left in the „wastebasket“ might also be due to biochemical abnormalities.'“ http://www.smithsez.com/Hypertension.html

Dr. Pfeiffers other books include Mental and Elemental Nutrients, The Healing Nutrients, Dr. Pfeiffers Total Nutrition, Nutritional Science and Cookery, and Neurobiology of the Trace Metals Zinc and Copper. His contributions to orthomolecular medicine live on through his writings, the clinics he inspired, and the annual Society of Ortho-molecular Medicine lecture that bears his name. A bibliography of Dr. Pfeiffers work is posted at http://www.doctoryourself.com/biblio_pfeiffer_ed.html


Alan Cott, M.D.
Hall of Fame 2004

Dr. Alan Cott fasted psychiatric patients while an attending physician at Gracie Square Hospital in New York City. In so doing, Lendon Smith, MD, writes that Dr. Cott was following the work of Dr. Yuri „Nicolayev of Moscow, who has fasted more than 10,000 mentally ill patients… The manic phase of manic depressive illness can be brought under control in the first week of a fast. Cott made them exercise by taking long walks. They drank two quarts of water every day as a minimum. If a patient failed to drink this amount, he terminated the fast… By the end of the first week, the medicines they had been on were usually discontinued.“

In addition to two popular books on supervised fasting, Dr. Cott wrote Dr. Cott’s Help for Your Learning Disabled Child: The Orthomolecular Treatment and was a frequent contributor to the Journal of Orthomolecular Psychiatry. His papers on Controlled Fasting Treatment for Schizophrenia and the Orthomolecular Approach to the Treatment of Learning Disabilities were presented at the Nutrition and Mental Health Hearing before the Select Senate Committee on Nutrition and Human Needs in 1977.


Linus Pauling, Ph.D.
Hall of Fame 2004

„Linus Pauling was right.“   — Associated Press

Orthomolecular medicine describes the practice of preventing and treating disease by providing the body with optimal amounts of substances which are natural to the body. Two-time Nobel Prize winner, and molecular biologist, Linus Pauling, Ph.D., coined the term „Orthomolecular“ in his 1968 article „Orthomolecular Psychiatry“ in the journal „Science“. Pauling described „Orthomolecular Psychiatry“ as the treatment of mental disease by the provision of the optimum molecular environment for the mind, especially the optimum concentrations of substances normally present in the body.

It was a natural progression for Pauling, who had identified sickle-cell anemia as the first molecular disease and subsequently laid the foundation for molecular biology, to then develop a theory that explained the molecular basis of vitamin therapy.

Orthomolecular is a term made up of ortho, which is Greek for „correct“ or „right“ and molecule which is the simplest structure that displays the characteristics of a compound. So it literally means the „right molecule“.

Pauling later broadened his definition to include orthomolecular medicine, which he defined as „the preservation of good health and the treatment of disease by varying the concentration in the human body of substances that are normally present in the body“. He stressed the adjective orthomolecular is used to express the idea of the right molecules in the right concentration. Pauling firmly believed that daily supplementation of vitamins in optimum amounts, in addition to following a healthy diet, was the most important step that anyone could take to live a long and healthy life, and by following his own advice, he lived productively for 93 years.

„Professor Pauling as always is ahead of his time. The latest research on vitamin C substantiates his twenty-five years of advocacy and investigation on the benefits of vitamin C.“ J. Daniel Kanofsky, MD, MPH, Albert Einstein College of Medicine.


Josef Issels, MD
Hall of Fame 2005

„Dr. Issels is an intelligent and profound clinician, with principles and applications of medical treatment which 1 admire.“
— Professor J. Anderson, King’s College Hospital, London

Dr. Josef Issels‘ roots were in the German tradition of ‚Naturheilverfahren‘ (natural practice). Because of his well-known professional skills, his kindness, and relatively high rate of survivors, many cancer patients in the terminal stage came to consult him. In 1951, one wealthy and grateful patient funded his private clinic, the Ringbergklinik in Rottach-Egern (Bavaria) with 36 beds. Issels‘ successful work continued until 1960, when he was arrested by the German ‚Kriminalpolizei‘ on the instigation of his medical opponents. He had to close down his clinic for years, in spite of a report from an independent scientist who had concluded that, of 252 terminal cancer patients with histologically proved metastases, 42 had survived for at least five years (17%) with the Issels therapy. For terminal patients, such a score is disproportionately high.

Issels believed that cancer was the end stage, the ultimate symptom, of a lifetime of immune system damage which had created an environment for the tumor to grow. Issels argued that conventional therapy just looked at the tumor without recognizing this longtime preconditioning period. Just cutting out or irradiating the tumor „mit Stahl und Strahl“ („with scalpel and radiation“) was not eradicating cancer. Instead, Dr. Issels saw the body as having great potential to heal itself. Good nutrition and a clean environment were central to his therapy. Like Dr. Max Gerson, he recognized the importance of detoxification.

In the end, Issels was proven to be right. From 1967 to 1970, Professor J. Anderson of King’s College Hospital and member of the World Health Organization inspected Issels‘ reopened clinic. He confirmed the highly significant survival rate of Issels‘ terminal cancer patients. His legacy is continued by the work of his wife, Ilsa and his son Christian.

Submitted by Dr. Gert Schuitemaker, President, 1S0M


William Kaufman, M.D., Ph.D.
Hall of Fame 2004

„I noted that niacinamide (alone or combined with other vitamins) in a thousand patient-years of use has caused no adverse side effects.“

Dr. William Kaufman was among the very first physicians to therapeutically employ megadoses of vitamin B3 (niacin, or niacinamide). He prescribed as much as 5,000 mg of niacinamide daily, in many divided doses, to dramatically improve and restore range of joint motion in arthritic patients. This groundbreaking work remains important to this day. In his 1949 book, The Common Form of Joint Dysfunction, Kaufman published the details of his niacinamide arthritis treatment, which also incorporated the use of vitamin C, thiamin, and riboflavin, all in large doses. He kept meticulous patient records that repeatedly verified the safety and effectiveness of megavitamin therapy.

Over 50 years ago, Kaufman showed remarkable foresight half a century into the future of orthomolecular medicine, describing how the lack of a just a single nutrient can cause diverse diseases, including what is now known as attention-deficit hyperactivity disorder. Charlotte Kaufman lovingly writes of her husband, „He was always ready to help someone else. He truly was a healer and a problem solver. He played the piano; he loved Mozart. He wrote poems, plays, essays, and subscribed to about 30 medical journals, which he read. He practiced medicine in his own way, without regard to fads or fashion. He seemed to know intuitively what the clinical answers were, but he was a thoughtful person who did not make decisions lightly. He was an independent thinker who was constantly studying and learning, not just from the printed word, but from his patients. He really listened to his patients. His main objective was to help people live healthy lives.“

Dr. Kaufman’s bibliography is posted at http://www.doctoryourself.com/biblio_kaufman.html


Emanuel Cheraskin, MD, DMD
Hall of Fame 2005

„Man is a food-dependent creature. If you don’t feed him, he will die. If you feed him improperly, part of him will die.“
— Emanuel Cheraskin

Emanuel Cheraskin, born in Philadelphia, received his M.D. from the University of Cincinnati College of Medicine. He was awarded his D.M.D in the first graduating class of University of Alabama School of Dentistry, where he would stay on for several decades as Chairman of the Department of Oral Medicine. Dr. Cheraskin was among the very first to recognize and demonstrate that oral health indicates total body health. He wrote over 700 scientific articles and authored or coauthored 17 textbooks, plus eight more books for the public, including the bestseller „Psychodietetics: Food as the Key to Emotional Health.“ His last two books, Vitamin C: Who Needs It? and Human Health and Homeostasis were published when he was past eighty. In addition to being a professor, physician and prolific author, Dr. Cheraskin was a singularly popular speaker. „Health is the fastest growing failing business in western civilization,“ he said. „Why is it so many of us are 40 going on 70, and so few 70 going on 40?“ The answer, he said, was our neglect of the paramount value of nutrition, an educational deficiency that Dr. Cheraskin devoted a lifetime to eradicating. Longtime friend Dr. Abram Hoffer writes: „Emanuel Cheraskin was a great scientist, investigator and physician. His papers are models of brevity, scientific clarity and productivity.“

Dr. Cheraskin’s educational legacy continues through the Cheraskin Archive in upstate New York, which contains the doctors lecture slides and copies of his papers in the care of Andrew Saul. His complete bibliography of books and papers is posted online at www.doctoryourself.com/biblio_cheraskin.html.

„Cherri,“ a regular speaker at the Nutritional Medicine Today Conferences, was always informative and entertaining. He last presented in Vancouver for our 25th conference in 1996, where he received the Orthomolecular Medicine Physician of the Year Award.


David Horrobin, MD, PhD
Hall of Fame 2005

David Horrobin was one of the most original scientific minds of his generation. His study of human physiology lead him to investigate the role of fatty acids and their derivatives in human disease. He applied his vast knowledge of lipids to investigate their therapeutic potential in medicine. David was a scholar of Balliol College, Oxford, where he obtained a First Class Honours medical degree. To this he added a clinical medical degree and a doctorate in neuroscience. He was a fellow of Magdalen College where he taught medicine alongside Dr. Hugh Sinclair, one of the pioneers in the field of essential fatty acids. After further research on EFAs at the universities of Newcastle and Montreal, he became increasingly fascinated in lipid biochemistry and its application to human disease.

Throughout his travels in East Africa and work in Kenya, he developed the kernel of thought about fatty acids, schizophrenia and its role in evolution. He later elaborated this idea in his 2001 book, The Madness of Adam and Eve, which was short-listed in 2002 for the Aventis Science Book of the Year. Abram Hoffer wrote: „This is a remarkable book. I agree with his interpretation that schizophrenia is an evolutionary advantage and that its genes are slowly moving into the general population.“

David was the founder and Editor of Medical Hypotheses, a forum for the dissemination of new ideas in medicine. He was also the founder and Editor of the journal Prostaglandins, Leukotrienes, and Essential Fatty Acids. He was a prolific writer who authored and edited numerous books on a wide range of subjects, as well as contributing to over 800 scientific publications. He served as Medical Adviser and President for the Schizophrenia Association of Great Britain. He also served on the board of the International Schizophrenia Foundation from 1998-2003.

Dr. Horrobin was a favourite speaker at the annual Nutritional Medicine Today Conference, where his presentations were models of clarity and logic.


Humphry Osmond, M.D.
Hall of Fame 2004

Linus Pauling wrote: „In 1967, I happened to read a number of papers published by two psychiatrists in Saskatchewan, Canada. Dr. Abram Hoffer and Dr. Humphry Osmond. (T)here was something extraordinary about their work. They were giving very large amounts of niacin to the schizophrenic patients, as much as 17,000 milligrams per day, which is 1,000 times the RDA. I was astonished that niacin and ascorbate, with the striking physiological property, when given in very small amounts, of preventing death from pellagra and scurvy, should be so lacking in toxicity that 1,000 times the effective daily intake could be taken by a person without harm. This meant that these substances were quite different from drugs, which are usually given to patients in amounts not much smaller than the lethal dosages.

I thought that these substances, normally present in the human body, and required for good health and life, deserved a name to distinguish them from ordinary Pharmaceuticals, and I decided to call them ‚orthomolecular‘ substances.“ (Linus Pauling in His Own Words: Selections from his Writings, Speeches and Interviews, edited by Barbara Marinacci. NY: Simon and Shuster, 1995.)

Dr. Humphry Osmond’s remarkable medical career included decades of distinguished psychiatric practice and a prodigious output of writing and research. He is widely recognized as a pioneer investigator into the chemistry of consciousness. Along with Dr. John Smythies, Osmond developed the theory that schizophrenics suffer due to endogenous production of an adrenalin-based hallucinogen. This led to the Hoffer-Osmond Adreno-chrome Hypothesis in the early 1950s, the very origin of orthomolecular medicine. The popular press may today remember Humphry Osmond for coining the term „psychedelic,“ but countless thousands of grateful patients will remember him as the co-discoverer of niacin therapy for schizophrenia. A bibliography of Dr. Osmond’s work is posted at http://www.doctoryourself.com/biblio_osmond.html

Memoriam By Abram Hoffer


Hugh Desaix Riordan, M.D.
Hall of Fame 2005
A Poetic Tribute to Abram Hoffer and Orthomolecular Medicine

„Hugh Riordan was an amazing influence on my family and on all who knew him.“
— Julie Hilton, The Hilton Family Foundation

Of all the medical mavericks, Hugh Riordan was one of the most knowledgeable, both as a maverick par excellence and as an historian of mavericks. Hugh was an orthomolecular fighter, who fought hard and consistently on behalf of orthomolecular concepts. He was challenged legally when he wanted to treat his patients with high dose vitamins in the hospital. He won. He was the first to demonstrate how large doses of vitamin C are chemotherapeutic for cancer patients. He was a pioneer in establishing the new vitamins-as-treatment paradigm.

„We worked together on the editorial board of the Journal of Orthomolecular Medicine, and on the board of the International Schizophrenia Foundation. Hugh joined the editorial board of JOM in 1991, then became Associate Editor in 2000. He published several books, including three volumes of Medical Mavericks, and about 70 clinical and research reports. His main work had to do with the schizophrenic syndrome and with the treatment of cancer using nontoxic vitamin C chemotherapy. Hugh was the leader in making available to cancer patients a treatment that is effective, safe, economical and very tolerable. Few oncologists have ever seen these advantages unless they visited Hugh’s clinic. The vitamin C intravenous chemotherapy studies established so well by Dr. Riordan are being continued at the University of Kansas and McGill University, Montreal. In 2002, Hugh was honored by International Society for Orthomolecular Medicine with the „Orthomolecular Physician of the Year“ award. He worked tirelessly, founding and developing the Center for the Improvement of Human Functioning International Inc. as a superb treatment center.“ This year, the Center celebrates its 30th anniversary. Hugh’s dedicated staff of more than 70 like-minded medical mavericks continue their founder’s pioneering work. (www.brightspot.org)

Submitted by Abram Hoffer, M.D., Ph.D.


Abram Hoffer, M.D., Ph.D.
Hall of Fame 2006

Abram Hoffer was an internationally recognized physician, author, medical researcher and pioneer in the use of vitamins and nutrients to treat disease. Dr. Hoffer has spent the past five decades conducting research related to the practice of orthomolecular medicine, which emphasizes the use of nutrients in optimum doses for the treatment of a wide range of diseases. His medical discoveries have been the topic of more than a dozen books and literally hundreds of research papers.

In 1952 he and his colleagues began developing a more effective treatment for schizophrenia that involved a biochemical hypothesis. They tried two nutrients: vitamin C and vitamin B3. He found that we could halve the two-year recovery rate of patients just by adding these vitamins to the program. This was the first major systematic attempt to use large dosages of vitamins therapeutically. In 1955 he also discovered that niacin lowered cholesterol levels.

More about Dr. Hoffer — his biography, books, research papers and homepage.

A Brief History of Orthomolecular Nutrition

A Brief History of Orthomolecular Nutrition



ORTHO HEALTHBy: C. Carleton-Fitchett, ROHP
Healing with Optimal Nutrition Based upon Biochemical Individuality: “When in doubt, try nutrition first”. – Roger J. Williams Ph.D. The term “orthomolecular” comes from the root words ‘ortho’ and ‘molecule’, meaning ‘correct molecules’ or (vitamins, minerals, amino acids, enzymes, and essential fatty acids) that are essential for the biochemistry and physiological functioning of the body.
Two –time Nobel Prize winner, and molecular biologist, Linus Pauling Ph.D., first coined the term “orthomolecular” in the journal of “Science” in 1968. Pauling referred to orthomolecular therapy as a means of health preservation and dis-ease prevention through varying the concentrations of substances normally present in the body. While Linus may have been the first to use the term “orthomolecular”, there are a number of pioneers in the concept of orthomolecular nutrition responsible for development and advancement in the use of varying diet and supplements for optimal health and healing.
Hipprocrates, a Greek physician referred to as the “father of medicine” is first credited with using food as a form of medicine more than 2500 years ago. He saw illness as the result of bodily imbalance and therapy was simply unlocking the body’s own inherent ability to re-balance and heal itself.
It was not until the 1700s that British navy phsycian, James Lind, conducted one of the first scientifically controlled medical experiments that showed lack of a specific nutrient created disease. Lind proved scurvy could be prevented with citrus fruits such as lemons, limes and oranges. Vitamin C deficiency was later identified and then recognized as the cause of scurvy. In 1893, Dutch physician, Chritiaan Eijkman discovered a diet consumed consisting primarily of polished rice, deficient in vitamin B, caused beriberi and other diseases.
Then in the late 1920s, Max Gerson, MD, found cancer patients typically suffered from toxicity and nutrient deficiencies. Gerson Therapy consisting of vegetable juices, and other natural therapies facilitated the filtration of liver toxins, and became known as a metabolic treatment that cleanses and strengthens the body’s ability to heal itself.
Later in 1937, Hungarian Albert Szent-Gyorgyi, Ph.D., won a Nobel prize for discovering and isolating ascorbic acid or vitamin C earlier identified as preventing scurvy.
Only a short fifty years ago, Toronto physician William J. McCormick M.D., found vitamin C deficiency a primary reason for many degenerative conditions and communicable illnesses. He advocated vitamin C as an antiviral and antibiotic.
Rodger J. Williams, Ph. D. (2004 Hall of Fame Inductee), advocated “the nutritional microenvironment of our body cells is crucially important to our health, and deficiencies in this environment constitute a major cause of disease.” Williams discovered pantothenic acid or vitamin B5.
Prior to world war II, Dutch physician, Cornelius Moerman (1898 – 1988), published his view on cancer and that ‘strengthening the immune system is the answer to this disease, and nutrition plays the central role’.
In 1933, Dr. Wilred and Evan Shute, defied conventional medicine’s understanding of disease, and used vitamin E to successfully treat and lower the incidence of heart disease. Their discoveries about vitamin E were largely suppressed by organized medicine who opposed nutrition being used to improve health.
In the early 1950’s, Dr. Frederick Klenner, produced consistent cures of a wide variety of viral and bacterial diseases using large doses of vitamin C.
In 1974, Dr. Carl Pfeiffer, furthered nutritional understanding, by relating trace element and mineral metabolism in schizophrenias. His research uncovered that biochemical imbalances were underlying many psychological issues. Pfeiffer said, “If there’s a drug that can alter the brain’s biochemistry, there’s usually a combination of nutrients that can achieve the same thing without side-effects.” Pfeiffer’s Law – “For every drug that benefits a patient, there is a natural substance that can achieve the same effect.”
Dr. Alan Cott in 1977,presented to the senate committee on nutrition, his research on therapeutic fasting and orthomolecular treatment for psychiatric patients and children with learning disabilities.
Dr. Josef Issels, (1907-1998), focused cancer treatment on nutrition and detoxification. He believed cancer was the by-product of lifelong immune system damage and it could not be eradicated with surgery or radiation.
William Kaufman, M.D.,(1910 -2000)treated arthritic patients with joint dysfunction using megadoses of vitamin B3 (niacin)and described dramatic improvement. He employed megavitamin therapy safely and effectively for a wide range of conditions to help people live healthier lives.
Dr. Cheraskin, (1916 – 2001)physician, dentist and lecturer, wrote many scientific articles and books on nutrition and was one of the first to relate oral health with total body health.
Dr. David Horrobin, (1939 – 2003) was one of the pioneer researchers of EFAs, lipid biochemistry and its correlation with disease.
Dr. Humphry Osmond, (1917 – 2004), co-discovered niacin therapy for schizophrenia and was a pioneer in the investigation of chemistry of consciousness.
Hugh Desaix Riordan M.D. (1932 – 2005), defended orthomolecular concepts, challenging the medical establishment to use high dose vitamins in hospital and was the first to show the chemotherapeutic effect of large doses of vitamin C for cancer, helping to establish vitamin therapy treatment.
Abram Hoffer, M.D., Ph.D.,(1917-2009) a physician, author, medical researcher and pioneer in orthomolecular treatment of disease. In the 1950’s, Dr. Hoffer co-developed treatment for schizophrenia using vit C and B3. He also discovered niacin’s cholesterol lowering capability. Dr. Hoffer moved to Victoria, British Columbia, Canada in 1976 where he practiced psychiatry for many years, and was a consultant in orthomolecular nutrition and in the proper use of vitamins. He was the illustrious President Emeritus of the International Schizophrenia Foundation and Journal of Orthomolecular Medicine, and a director of the International Organization of Nutritional Consultants (IONC). Dr. Hoffer believed orthomolecular nutrition to be the future of all the healing arts and professions and consulted with IONC on the addition of the designation, Registered Orthomolecular Health Practitioner (ROHP).
DICTIONARY (Wikipedia resource)
Ortho – (from the Greek word meaning “straight” or “correct”) Molecular – of, relating to, or consisting of molecules. Molecule – [L. Molecula, little mass]. The smallest quantity into which a substance may be divided without loss of its characteristics. Health – [AS. Health, wholeness]. A condition in which all functions of the body and mind are normally active.
Practitioner – Someone who engages in an occupation, profession, religion, or way of life. Even if the person has been practicing their entire life or has a PHD in the subject they will always be known as a Practitioner.
Orthomolecular – Indicating the normal chemical constituents of the body or the restoration of those constituents to normal. Orthobiosis – [“ + bios, life]. Right living. A term used by Metchnikoff to encompass all the factors that may affect longevity and well-being.
Health is the level of functional or metabolic efficiency of a living organism. In humans, it is the general condition of a person’s mind and body, usually meaning to be free from illness, injury or pain (as in “good health” or “healthy”).[1] The World Health Organization (WHO) defined health in its broader sense in 1946 as “a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity

ORTHOMOLECULAR MEDICINE – When Two Worlds of Medicine Clash

ORTHOMOLECULAR MEDICINE – When Two Worlds of Medicine Clash … Orthomolecular Comes Up a Winner

by Helke Ferrie RSS

Early in April, at the height of the SARS scare, among the many events cancelled in Toronto was the conference of the International Society of Cancer Researchers (15,000 registered to attend) because they feared contracting or taking home the SARS virus. However, the 32nd annual conference of the International Society for Orthomolecular Medicine (ISOM) never even considered cancelling. In his welcoming address Dr. Gert Schuitemaker explained, “We have no fear of contracting or passing on SARS. We just increase our daily doses of vitamin C, selenium and zinc and we know we are just fine.”

The contrast between these two utterly different worlds of modern medicine is astounding: the high-tech crowd is scared and admits helplessness. The low-tech crowd fears nothing, because their medicine is founded on an insight that confers ultimate personal and scientific security, best summed up in the words of the 18th century scientist Francis Bacon who observed, “We control Nature by obeying her.”


The assumptions informing the SARS scare are similar to ancient fears of angry, arbitrary gods who need to be understood (sequence the virus‚ genome) and propitiated with their very own ritual to be observed in perpetuity (develop a vaccine) which is very lucrative for the high priests (pharmaceutical companies). By contrast, understanding disease in terms of orthomolecular medicine places physicians and patients into an intelligent dialogue with Nature’s healing powers.

Not surprising to an orthomolecular doctor is the fact that SARS mortality (326 dead worldwide by May) involved only people who were immune-compromised through bad nutrition or pre-existing health conditions (Lancet, May 3, 2003). SARS patients develop viral pneumonia, potentially fatal due to the destruction of the oxygen-carrying alveoli in the lungs. An inflammation-producing protein, known as tumor necrosis factor, is overproduced as the immune system goes into hyper-alarm. Standard medicine combats that with steroids and anti-viral drugs, which can cause dangerous anemia and suppress the immune system — that system which sounded its alarm in the first place because it was already too weak to fight.

Compared to orthomolecular medicine, this standard medical reasoning strikes one as disturbingly prehistoric. What a SARS patient really needs is a boost to the immune system, not its suppression. Paradoxically, standard medicine agrees that recovery depends entirely on the immune system eventually mounting a successful defence against the virus. The only substances which enable such a defence are vitamins C and E, the minerals selenium and zinc, and bioflavonoids like quercetin and myricetin (found in organically grown red onions, apple peel, berries, tea, wine, and certain vegetables). Why standard medicine doesn’t read the mainstream journals, such as the Journal of Medical Virology is a mystery, for there the information is found on how these substances in mega-doses kill both RNA and DNA viruses by boosting the immune system into appropriate responses. (Basic biochemistry fortunately informs the Beijing zookeepers: they are feeding their animals huge amounts of vitamins to ensure they don’t catch SARS (New York Times, May 10, 2003).)

Not only did the ill-prepared immune systems of some people over-react dangerously to SARS, but so did the whole world, according to virus expert and Nobel laureate David Baltimore, Stephen Lewis of the UN’s AIDS program, and the relief organization Doctors Without Borders. They pointed out that over the last six months, a North American had a 10,000 times greater chance of dying from ordinary flu than from SARS (every day 55 people die of regular flu).


SARS may be more than another nasty virus. One of the key Canadian SARS researchers, Dr. Frank Plummer of Canada’s National Microbiology Laboratory, disagreed with the World Health Organization’s assertion that SARS is caused by a specific corona virus, because only 40% of SARS patients tested were found to have it. Corona viruses mutate often in hours, but strangely this one didn’t change in seven weeks. Really “weird” said Dr. Plummer, is the fact that the SARS samples taken from people all over the world were genetically identical — a unique finding for a virus which adapts rapidly to local conditions and ought to have been different in every sample. Furthermore, some people who recovered from this virus became ill again, yet same-strain coronavirus infections were totally unknown, until now.

Fundamentally unnatural is the fact that this virus is a hybrid: one side is like a virus that causes respiratory disease, the other looks like one that causes hepatitis and pneumonia (New Scientist, April 26, 2003). Nature does not go in for genetic recombinant technology. Are 60% of cases just regular viral pneumonia patients? And are the remaining 40% “real” SARS cases the result of an experiment gone wrong, as speculated in the international journal Virology (No. 77, 2003)?

Indeed Canada’s University of Western Ontario virologist and anti-GMO activist Professor Joe Cummins wonders why the “large body of reports on the genetic manipulation of corona viruses” is ignored and suggests that the SARS virus might well be “a unique virus that arose as a laboratory accident or purposeful experiment.” (From interview with Bill Sardi.)

What we do know is that the biotech companies Prodigene and Monsanto have used coronaviruses to make an oral livestock vaccine (projected market: US $140 billion by 2020). Indeed, it is vaccines that all biotech companies are now pinning their hopes on, as reported in Nature (April 24, 2003), since the “industry is battling for survival.” Biotech stocks have fallen by 50% in the past two years because of waning investor confidence and increasing worldwide rejection of GMO foods.

Interestingly, China had granted permits for those vaccine experiments and China’s Guangdong province is the epicentre of classic SARS from where it spread across the world.


The late great chemist Linus Pauling (two time Nobel prize winner) coined the term “orthomolecular” in 1968, meaning “right molecule”: “Treatment of disease is a matter of varying the concentration of substances (right molecules) normally present in the body.” Orthomolecular medicine is based on two principles: First, illness is seen as a biochemical alarm reaction caused by inadequately nourished cells unable to support bodily systems. Specific vitamins, amino acids, minerals, coenzymes etc. need replenishing to restore function. Inadequate nutrition comes from processed foods and pesticides which kill essential nutrients, a repetitive mono-diet lacking sufficient organic fresh fruits and vegetables, and acquired addictions to sugar, alcohol, tobacco, and other toxic substances such as artificial sweeteners and anti-depressant drugs.

Second, it is acknowledged that everybody is biochemically different due to variation in the personal history of biological and emotional stress, nutrition, genetic endowment, and cultural habits. Orthomolecular medicine has broad therapeutic guidelines, which are then fine-tuned to individual needs. Even hereditary diseases are seen as indications that this person has unusual requirements for a specific nutrient. Treatment involves nutrients because drugs (temporarily useful in an emergency) are designed to interfere with the body’s dynamics, i.e. its enzyme system, while nutrients always and unfailingly work as constructive helpers for those enzymes.


This year’s Orthomolecular Conference was dedicated to the memory of David Horrobin who sadly died in his 50s on April 1. He lived long enough to see his life’s work on the diseases caused by essential fatty acid (EFA) deficiencies replicated and accepted by mainstream medicine. Harvard University and Johns Hopkins Medical school confirmed that EFAs are the central players in a family of conditions ranging from hyperactivity to schizophrenia and include diabetes, thyroid diseases, asthma and allergies (Medical Post, April 29, 2003). (Horrobin began his research career after being fired as medical director from a New York psychiatric hospital in the 1970s because his dietary interventions cured even the most chronic mental patients so rapidly that hospital profits were threatened.) Horrobin’s research was the largest and most successful assault on poisons like Ritalin and antidepressants.

This conference always begins with a “Forum” at which patients speak of their experiences with orthomolecular medicine. The Forum has been organized for years by Robert Sealey, a chartered accountant whose mind and life were saved by Dr. Hoffer after escaping the living hell of standard psychiatry. Sealey’s books now offer practical help and guidance for victims of mental disorders. He is of special help to people whose manic-depression wrecked their finances, as he can show them the road back to financial and mental balance.

This year, the Forum testimonies included a Princeton University theologian who suffered a cortisone-induced psychosis after contact with poison oak. Misdiagnosed for years and drugged out of whatever mind remained, she finally was rescued and now rescues others from the same possible fate. In another testimony, a young musician and his mother described the descent into florid insanity (and the painstaking, dramatic stages of complete recovery) following exposure to street drugs, allergy-inducing foods, and an especially high sensitivity to the toxicity of tobacco. As well, the film by Hollywood star Margot Kidder (of Superman), Masks of Madness, was also shown.

It is impossible to attend a Forum meeting and not be profoundly shaken and overwhelmingly grateful that doctors like Abraham Hoffer exist in this world.

The scientific presentations, in addition to Dr. Hoffer’s marvellous overview of the history of orthomolecular medicine, included presentations on new discoveries about vitamin B3 by Dr. Jonathan Prousky, vitamin D by Dr. Reinhold Vieth, and addiction research into curing alcoholism, street drugs and antidepressants by Dr. Joan Mathews Larson. These presentations were so outstanding, the reader is urged to order the tapes and organize their own orthomolecular conference at home for family and friends.

Dr. Hoffer told how in the 1950s he realized one day that the chemical structure of mescaline, LSD, and certain proteins our bodies produce under stress are all hallucinogens. Testing his psychiatric patients confirmed this insight, which eventually led to the understanding that such stress-based imbalances were mediated through the lack of EFAs, as Dr. Horrobin later proved. Dr. Prousky reported of his successful new uses of vitamin B3 (niacin) for classic migraine, for example. The flush-producing pure B3 opens the constricted blood supply within minutes. In severe allergic reactions B3 works quickly and dramatically because it causes T cells to release the body’s healing histamine.

Dr. Vieth, a Canadian researcher and world expert on vitamin D reported on the new Recommended Daily Allowances based on his work, namely a minimum of 1,000 units daily. His research explores this vitamin’s effect on preventing osteoporosis, cancer and chronic disease. Dr. Larson is internationally famous for her work with alcoholism treated as a nutritional deficiency response. While Alcoholics Anonymous can claim only a success rate of 40% (followed up for seven years), her treatment boasts a success rate of 75% followed up over 20 years. Her work now has expanded to include curing victims of food-mediated and anti-depressant-induced addictions. The case histories she reported from her institute were jaw-droppers. An extraordinary experience in childhood is what eventually guided her towards orthomolecular medicine: Her family had invited a blind child for a summer vacation and, along with the other children in the house, the guest had been given cod liver oil daily. By the end of the summer the child’s sight was fully restored.

The conference also celebrated Dr. Hoffer’s 85th birthday. Having spent his life showing how processed, sugar-laden foods cause mental and physical illness, it comes as sweet vindication that the World Health Organization published its report, “Diet, Nutrition and the Prevention of Chronic Disease” on April 23. In it the WHO tells the food and soft drink industry to reduce sugar to 10% of caloric intake from 25%, and remove vending machines from schools. As reported in The Medical Post, May 13, 2003, the Sugar Association’s president Andrew Briscoe wrote to the WHO Director-General that he would see to it that the U.S. would stop its financial contribution to the WHO if the report were not withdrawn. The WHO made the threat public and stood firm.

Are intimations of a Golden Age of Medicine coming into focus, promising that medicine will serve humanity once again instead of Big Business? History has given us some intimations of the epidemiology of good nutrition: During World War I, Denmark suffered a severe drought as well as the Allied food blockade. So the Danish government slaughtered 80% of the country’s livestock and fed the grain (mostly vitamin- and mineral-rich rye and wheat bran) to its citizens instead. As a result, mortality from all causes fell by 17% and when the great pandemic influenza of 1918 struck (killing 40 million people worldwide in one year), Denmark was virtually spared completely. And another story from European history goes: In England during World War II, refined flour became unavailable. As a result, the population was healthier after the war than before.

In addition to the need for healthy food, a genuine “war on drugs” is needed — those mostly symptom-controlling and nutrient-depleting pharmaceutical phantoms on which our government spends annually $2 billion more than on medical services (Medical Post, May 13, 2003).

Those and the genetically engineered freaks the food industry tries to force us to eat are, however, most successfully combated by consumer resistance and conscious engagement with “the right molecules.” An orthomolecular way of life offers the way to health.


• J.M. Larson, Seven Weeks To Sobriety, Ballantine, 1997
• J.M. Larson, Depression-Free Naturally, Ballantine, 2001
• A. Hoffer, M.D., Orthomolecular Medicine for Physicians, Keats, 1989
• A. Hoffer, M.D., Vitamin C & Cancer: Discovery, Recovery, Controversy, Quarry Books, 2000
• A. Hoffer, M.D., Hoffer’s Laws of Natural Nutrition, Quarry, 2001
• A. Hoffer, M.D., Vitamin B-3 and Schizophrenia, Quarry, 1998
• A. Hoffer, M.D., Dr. Hoffer’s ABC of Natural Nutrition for Children, Quarry, 1999
• A. Hoffer, M.D., Putting It All Together: The New Orthomolecular Nutrition, Keats, 1996
• D. Horrobin ed., R.P. Huemer ed., The Roots of Molecular Medicine: A Tribute to Linus Pauling, Freeman, 1986
• M. Lyon, M.D., Healing The Hyperactive Brain, Focused Publishing, 2000
• R. Sealey, Finding Care for Depression, Sear Publications, 2002
• S. Simmie & J. Nunes, The Last Taboo, McClelland & Stewart, 2002
• R. J. Williams MD et al, A Physician’s Handbook on Orthomolecular Medicine, Keats, 1979
• R.J. Williams, Biochemical Individuality, Keats, 1998

• The conference presentations are available on tape from Audio Archives (905) 889-6555

Finding orthomolecular medical practitioners:
• International Society for Orthomolecular Medicine (chapters in 17 countries); in Toronto: (416) 733-2117, e-mail: centre@orthomed.org
• The Naturopathic Medical Research Clinic, Toronto (416) 944-8824, www.nmrc.ca, e-mail: info@nmr.ca
• Canadian College of Naturopathic Medicine, Toronto www.ccnm.edu
• Joan M. Larson’s Health Recovery Centre, Minneapolis, MN, USA, offers intensive treatment for recovery from alcoholism, suicidal depression, addiction to anti-depressants 1-800-554-9155 or (612) 827-7800
• Mood Disorder Association of Ontario, (416) 486-8049, www.mooddisorders.on.ca

For a comprehensive overview of SARS and systemic biases blinkering medicine see Bill Sardi’s May 2003 report on the Knowledge of Health website: http://askbillsardi.com/sdm.asp

For full information on how to treat and prevent SARS, and any other viral disease, see Dr. Jozeph Pule’s website, the founder of the World Natural Health Organization: www.wnho.net

In Canada see www.HealthyWorldDistributing.com or 1-888-508-4787 or john@cureforsars.net (1-800-336-9266).

Other recommended and reliable sources are www.drhui.com, www.garynull.com and www.orthomed.com

One Person’s WRAP Plan – Recovery Using Restorative Orthomolecular Medicine

One Person’s WRAP Plan – Recovery Using Restorative Orthomolecular Medicine

One Person’s WRAP Plan

by Robert Sealey, BSc, CA

Robert Sealey is the author of Finding Care for Depression, Mental Episodes & Brain Disorders.

My symptoms recurred over 28 years: on-again off-again episodes of depression with anxiety, dark thoughts and blue moods interspersed with high-energy phases and irritable outbursts. Robert SealyPeriodically, I consulted physicians, psychologists and psychiatrists. As a trusting and a cooperative patient, I tried pills and therapy but was dismissed, misdiagnosed, mistreated, lied to and laughed at. At age 45, I was finally diagnosed with a bipolar II mood disorder, a form of manic depression. For the first time, I had the right medical words to understand myself. I wasn’t mad, sad or bad, just a person with a mood disorder.

Desperate for help, I updated my Bachelor of Science degree (in biological and medical sciences and psychology) by studying self-help books, psychiatry texts and psychology references. Alone with my symptoms, I needed the reassurance that comes from learning how other people cope with mental problems. Even though I was not well, The Depression Workbook: A Guide for Living With Depression and Manic Depression by Mary Ellen Copeland inspired me to learn and renewed my hope for recovery.  Reading became my first wellness recovery tool.

Eventually I read the practice guidelines of psychiatry. They recommend accurate diagnosis and effective treatments. Would any competent psychiatrist short cut the guidelines by just labeling a sick patient as depressed, bipolar or disordered, without diagnostic tests? Why rush to prescribe pills like antidepressants, tranquilizers, anticonvulsants and mood stabilizers? Lithium for bipolars, SSRIs for depressives. Sounds quick and easy but what if the medications make a sick patient worse? What if a misdiagnosis leads to a misprescription? For months as my pills made me worse, I thought about suicide – I just wanted the pain to end. As my doctor increased the doses, I deteriorated. I desperately wanted to recover.

Nobody likes it when a moody patient gets sicker, not the doctor, not the family and certainly not the patient. The system has three labels for the worst cases – refractory depression, treatment resistance and borderline personality. My psychiatrist, a published expert specializing in mood disorders, wrote ‘The Clinical Meaning of Refractory Depression’ for the American Journal of Psychiatry in which he defined “refractory depression” as problems with diagnosis and problems with treatment. That brainy expert repeatedly noted “refractory depression” in my medical file and kept writing prescriptions. He did not revisit my diagnosis or revise my treatment plan. While I deteriorated, he short-cut 13 standard procedures. For months, he increased doses and smiled as his pills caused side attacks and toxic effects.

The stigma of a chronic mental illness distances depressives from healthy friends and family. Fault-finding and excluding do not help when sick people need medical care, encouragement and support. Instinctively I sought other people with similar problems, hoping to learn how they got well. Networking became my second wellness recovery tool. At mood disorder association meetings, I met people with diagnoses like depression, manic depression and dysthymia. Most of them were anxious and unsettled, wondering about their symptoms, treatments and prognosis. I felt comfortable with my moody tribe, welcomed and understood. While discussing our problems, we monitored our progress. We compared symptoms, side effects, diagnoses and therapies. Some people did well on high doses of meds, while others, like me, could not tolerate even low doses of our brain pills. Some talk therapies helped us improve our patterns of thinking, feeling and behaving but it was hard to make progress when we were sick.

I started an independent depression project and interviewed more than 150 depressed people and family members, while studying the mental health care system and researching books and articles. One woman suggested the Journal of Orthomolecular Medicine. Imagine my surprise to find helpful information about restorative care just two miles from home in Toronto. The friendly editor of the Journal Of Medicine offered their booklist, newsletter and annual conference. Still cranky after years of bad moods and failed treatments, I could not resist this pleasant invitation to read about restorative care. My curiosity was aroused by the scientific and medical research, the fifty year history and success of orthomolecular medicine and the progress reports of recovered patients. Would ortho-care heal my brain?

Skeptical, I tried a third wellness recovery tool-orthomolecular medicine. Disillusioned after years of failed doctor-patient relationships and determined to avoid short cuts, I read about orthomolecular health professionals who apply the life science of biochemistry to the art of medicine. Thanks to a little yellow book, The Way Up From Down, by California psychiatrist Dr. Priscilla Slagle, whose own mood disorder resolved when she tried orthomolecular medicine, I learned how to take nutritional supplements. I had already responded quickly to an extract of the world’s oldest plant, gingko biloba but some symptoms continued. A basic orthomolecular regimen of vitamins, minerals and amino acids, taken one by one and continued if they helped, soon restored my mental health.

At conferences in Toronto and Vancouver, I met recovered patients and interviewed orthomolecular doctors. I read many books about orthomolecular medicine, intrigued by the work of Dr. Abram Hoffer, whose >30 books include Adventures in Psychiatry: The Scientific Memoirs of Dr. Abram Hoffer. He and his colleague Dr. Humphrey Osmond co-founded orthomolecular medicine in Canada in the 1950s while researching schizophrenia, developing an adrenochrome theory and customizing restorative regimens for psychotic patients.  Their regimen for schizophrenia did not work for me; my diagnosis of bipolar disorder meant that I needed a different regimen.  Nutrition & Mental Illness by Dr. Carl Pfeiffer, another colleague of Dr. Hoffer’s, explained how one of three regimens could help depending on each patient’s diagnosis and biochemical individuality. Dr. Pfeiffer’s histamine-lowering regimen worked best for me.

The orthomolecular concept makes sense. A depressed brain needs to “refuel” its energy, stabilize its enzymes, balance its neurotransmitters and restore its capabilities. As a sick brain heals, symptoms resolve. The restored brain no longer misfires; bad moods pass; life looks brighter. A bipolar brain also needs to control its tendency to get overexcited. Fortunately, GABA, the brain’s inhibitory neurotransmitter, taken as a supplement, calmed me right away. I added TMG (trimethylglycine) and l-taurine and the trace minerals magnesium, zinc and manganese. They worked! With Dr. Slagle’s book as a professional guide, I slowly tested the B vitamins 1, 2, 5, 6 and 12, vitamin D and the antioxidant vitamins C and E. Guided by other books and two doctors, I am taking mitochondrial supplements l-carnitine with ribose and co-enzyme Q-10 and the trace minerals chromium and selenium.

At age 50, new symptoms started – difficulty sleeping, problems with memory and focus, low energy and low libido. After reading a newspaper article about a male hormone deficiency, I found a family doctor who would prescribe testosterone supplements. That helped right away. I got a second opinion from Dr. Jerald Bain, a Toronto endocrinologist and medical professor who specializes in andropause and edited Mechanisms in Andropause. Under his care, I continued my bipolar regimen and adjusted the supplements of testosterone, which also works – restoratively.

Since 1996, an orthomolecular regimen of vitamins, minerals, amino acids, energy and enzyme co-factors, essential fatty acids, hormones and antioxidants has complemented my antidepressant-anxiolytic medication (an extract of gingko biloba). I have been stable for ten years, with no more episodes of depression or hypomania. After years of painful problems, black and blue moods and symptoms of a bipolar II mood disorder, migraines and anxiety, restorative care helped me recover and stay well.

Volunteering became my fourth wellness recovery tool. As an independent volunteer, I can help myself keep well while helping the International Society of Orthomolecular Medicine with their Open Minds campaign – orthomolecular public education and networking. Ten years ago, I started writing books and articles and telling people about restorative care. I appeared in the documentary film Masks of Madness: Science of Healing and spoke at four conferences Nutritional Medicine Today. When people ask about my books or web site www.searpubl.ca I introduce them to restorative orthomolecular care.

I worked hard to develop a wellness recovery action plan which has four key tools: (1) bibliotherapy (reading books by recovered patients and health professionals), (2) networking (with support organizations, patients, caregivers and physicians), (3) taking a daily orthomolecular regimen and (4) volunteering. My bipolar brain is not perfect, but perfectly good enough to work, get along with family and friends, consult with clients, write, network and tell people about orthomolecular medicine: restorative treatments for beautiful minds. Even when things get tough, my W.R.A.P. tools help me find competent health professionals, ask for quality medical care, avoid relapse and live well with a bipolar II mood disorder.

From Robert Sealey:

New books, just out, with more about orthomolecular medicine — —

Mental Health Regained – by Dr. Abram Hoffer
just out from the Intnl. Schizophrenia Foundation
-18 orthomolecular recovery stories – bipolars and schizophrenics, compiled

Healing Depression & Bipolar Disorder Without Drugs – by Gracelyn Guyol
inspiring storiesof Restoring Mental Health Through Natural Therapies
– from Conn, US – she recovered from bipolar disorder and celiac, using orthomolecular methods, found 13 other people
– currently going across the US speaking at PESI seminars

What Your Doctors May NOT Tell You About Depression: The Breakthrough Integrative Approach for Effective Treatment  – by Michael Schachter, MD
– an orthomolecular doctor from New York
– published in the Journal of Orthomolecular Medicine

Living Well with Depression and Bipolar Disorder:
What Your Doctor Doesn’t Tell you That You Need to Know – by John McManamy
– Chapter 15 – complementary treatments has several pages about orthomolecular medicine.
John did not know about orthomolecular medicine, but I told him my story
and he evidently researched from others for his book.

Manic-Depressive Illness
Second Edition
-mentions nutritional and orthomolecular psychiatry on pages 791 to 793 of 1262
Goodwin & Jamison